![]() ![]() Using the optimal condition, we achieved high capture efficiency of ssDNAs (86.7%) which showed good potential to be further extended for the analysis of CpG sites in cancer-related genes. Structural changes of the nanowires while varying the number of ALD cycles were evaluated by statistical analysis and their relationship with the capture efficiency was investigated. ZnO SiO2 Core Shell Nanoparticles: The properties of core-shell composites depend heavily on the materials constituting both the core and the shell parts. We hypothesized that finding the optimum number of ALD cycles would be crucial to ensure adequate coating for successful tuning to the desired surface properties, besides promoting a sufficient trapping region with optimal spacing size for capturing the ssDNAs as the biomolecules traverse through the dispersed nanowires. In this research, we modified the surface of ZnO nanowires through ALD for the fabrication of a ZnO/SiO 2 (core/shell) nanowire microfluidic device which we utilized for the capture of CpG-rich single-stranded DNAs (ssDNA). Simply, 0.1gm of SnO 2 /ZnO nanostructures was dispersed in 50ml of ethanol under constant stirring and the solution was further processed to ultrasonication for complete dispersion of the particles. Structural changes of the nanowires while varying the number of ALD cycles were evaluated by statistical analysis and their relationship with the capture efficiency was investigated. /ZnO/SiO 2 core-shell-shell nanospheres SiO2 covered SnO2/ZnO nanospheres were prepared through a versatile Stber method as follows2. In this research, we modified the surface of ZnO nanowires through ALD for the fabrication of a ZnO/SiO 2 (core/shell) nanowire microfluidic device which we utilized for the capture of CpG-rich single-stranded DNAs (ssDNA). Atomic layer deposition (ALD) is capable of providing an ultrathin layer on high-aspect ratio structures with good conformality and tunable film properties. ![]()
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